Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1,636
Tocris Bioscience™ 3-Azido-7-hydroxycoumarin
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Click-reactive fluorescent dye
1,637
Tocris Bioscience™ L-655,708
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CAS: 130477-52-0 Molecular Formula: C18H19N3O4
| CAS | 130477-52-0 |
|---|---|
| Molecular Formula | C18H19N3O4 |
1,638
Tocris Bioscience™ CID 755673
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CAS: 521937-07-5 Molecular Formula: C12H11NO3
| CAS | 521937-07-5 |
|---|---|
| Molecular Formula | C12H11NO3 |
1,639
Tocris Bioscience™ Src I1
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Dual site Src kinase inhibitor
| Inhibitors | Src I1 |
|---|---|
| Product Type | Src I1 |
| Molecular Weight (g/mol) | 373.4 |
| Purity | >99% |
1,640
Tocris Bioscience™ NVS PAK1 C
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Negative control of NVS PAK1 1
| Purity | 98% |
|---|---|
| Recommended Storage | Store at -20°C |
| Synonym | (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide |
| Molecular Formula | C22H23ClF3N5O |
| Formula Weight | 465.91 |
1,641
Tocris Bioscience™ ML 382
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MrgX1 (SNSR4) positive allosteric modulator
| Target | Sensory Neuron-Specific Receptor Agonists |
|---|---|
| CAS | 1646499-97-9 |
| Purity | >98% |
| Chemical Name or Material | Mas-Related G Protein Coupled Receptor Modulators |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C18H20N2O4S |
| Formula Weight | 360.43 |
1,642
Tocris Bioscience™ PPTN hydrochloride
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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High affinity and selective P2Y14 antagonist
1,643
Tocris Bioscience™ Tariquidar dihydrochloride
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Potent P-glycoprotein (P-gp) inhibitor
| Target | Multidrug Transporter Inhibitors |
|---|---|
| CAS | 1992047-62-7 |
| Purity | >98% |
| Chemical Name or Material | N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C38H38N4O6.2HCl |
| Formula Weight | 719.66 |
1,644
Tocris Bioscience™ TDZD 8
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Selective non-ATP competitive inhibitor of GSK 3β
| CAS | 327036-89-5 |
|---|---|
| Product Type | Inhibitor |
| Color | White |
| Solubility | Soluble to 100mM in DMSO, 100mM in ethanol |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C10H10N2O2S |
| Formula Weight | 222.26g/mol |
1,645
Tocris Bioscience™ Rucaparib camsylate
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PARP inhibitor
| Target | Poly(ADP-ribose) Polymerase Inhibitors |
|---|---|
| CAS | 1859053-21-6 |
| Purity | 98% |
| Chemical Name or Material | 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6 H-pyrrolo[4,3,2,ef][2 ]benzazepin-6-one (1 S,4 R)-7,7-dimethyl-2-oxobicyclo[2.2.1 ]heptane-1-methanesulfonic acid |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H18FN3O.C10H16O4S |
| Formula Weight | Observed MW: 555.66 |
| Assay Percent Range | >98% |
1,646
Tocris Bioscience™ PP 242
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Dual mTORC1/mTORC2 inhibitor
| CAS | 1092351-67-1 |
|---|---|
| Chemical Name or Material | 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C16H16N6O |
| Formula Weight | Observed MW: 308.34 |
| Assay Percent Range | >98% |
1,647
Tocris Bioscience™ Liproxstatin-1 hydrochloride
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Additional Apoptosis-related Compounds
| Target | Ferroptosis Inhibitors |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Synonym | N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine hydrochloride |
| Molecular Formula | C19H21ClN4.HCl |
| Formula Weight | 377.31 |
1,648
Tocris Bioscience™ GSK 1016790A
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Potent TRPV4 agonist
| Product Type | Agonist |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C28H32Cl2N4O6S2 |
| Formula Weight | 655.61 |
1,649
Tocris Bioscience™ A 410099.1
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High affinity XIAP antagonist
| Product Type | Antagonist |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C27H40N4O3.HCl |
| Formula Weight | 505.09 |
1,650
Tocris Bioscience™ NVP 2
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Potent and selective ATP-competitive CDK9 inhibitor